Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH.

Dinesh Mani TripathiSumati RohillaImpreet KaurHamda SiddiquiPreety RawalPinky JunejaVikash KumarAnupama KumariVegi Ganga Modi NaiduSeeram Ramakrishna Subham BanerjeeRekha PuriaShiv K SarinSavneet Kaur

Published in: International journal of molecular sciences (2021)

In vivo LSEC-specific silencing of RUNX1 using immunonano-lipocarriers encapsulated siRNA effectively reduces its expression of adhesion molecules, infiltrate on of immune cells in liver, and inflammation in NASH.

Keyphrases

oxidative stress
transcription factor
endothelial cells
poor prognosis
cancer therapy
escherichia coli
long non coding rna
drug delivery
staphylococcus aureus
biofilm formation
cell migration
vascular endothelial growth factor