Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells.
Chika NatsumeNao AokiTomoko AoyamaKeisuke SendaMio MatsuiAiri IkegamiKosuke TanakaYasu-Taka AzumaTakashi FujitaPublished in: International journal of molecular sciences (2020)
Fucoxanthin (FX) is a xanthophyll that is contained abundantly in marine plants. The biological action of FX includes its antioxidant and anti-lipogenic activities, while the precise action of its mechanisms on skin cells has not yet been clarified. The current study examined the effect of FX in comparison with tacrolimus (TAC) on NC/Nga mice, which are an atopic dermatitis (AD) model. FX topical treatment dramatically ameliorated itching behavior over the TAC treatment, which was insufficient for improvement of AD symptoms. In Nc/Nga mice, FX or TAC applied to the skin inhibited eosinophil infiltration with decreased expression of Il-33. FX also stimulated Il-2, Il-5, Il-13, Il-10, and TGF-β expression levels, and Sca1+Il-10+TGF-β+ regulatory innate lymphoid cells (ILCreg) were dominantly observed in FX treated skin epidermal keratinocytes and dermal layers. This combined evidence demonstrated that FX exerts anti-inflammatory effects on keratinocytes and ameliorates AD symptoms by regulating ILCreg to normalize immune responses in an atopic dermatitis model.
Keyphrases
- atopic dermatitis
- wound healing
- induced apoptosis
- cell cycle arrest
- anti inflammatory
- poor prognosis
- immune response
- soft tissue
- oxidative stress
- transcription factor
- type diabetes
- physical activity
- signaling pathway
- toll like receptor
- high fat diet induced
- epithelial mesenchymal transition
- adipose tissue
- dendritic cells
- binding protein
- newly diagnosed
- skeletal muscle