SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.
Jingyuan LiXue WanDan XieHui YuanQin PeiYanan LuoYiyu ChenJiawen XianTing YePublished in: Cell death & disease (2023)
Our study reveals a novel mechanism by which SPDEF transcriptionally activates GALNT7 via directly binding to its promoter to promote cell proliferation, motility and stemness, and led to luminal BC tumorigenesis and poor prognosis.