Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe.
Farihah MalikSiobhan CrichtonYulia PlotnikovaInga LatyshevaAnna SamarinaMaria Pokorska-ŚpiewakMarisa Navarro GomezHeather BaileyClaire ThorneAli JuddAnna TurkovaIntira Jeannie CollinsPublished in: The Pediatric infectious disease journal (2024)
We evaluated the effectiveness and safety of direct-acting antivirals in adolescents with hepatitis C (HCV)/HIV coinfection using pooled individual patient-level data from 5 European cohorts. Of 122 participants in follow-up from November 2013 to August 2021, 19 were treated <18 years of age; of 15 with HCV RNA available at/after 12 weeks post-treatment, all had sustained virologic response with acceptable safety. This evidence addresses an important gap in knowledge of treatment outcomes in adolescents with HCV/HIV coinfection in real-life settings.
Keyphrases
- hepatitis c virus
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- young adults
- hiv positive
- hiv testing
- physical activity
- hiv aids
- men who have sex with men
- healthcare
- big data
- randomized controlled trial
- combination therapy
- clinical trial
- deep learning
- replacement therapy
- open label
- data analysis
- machine learning
- study protocol
- nucleic acid
- double blind