A Systematic Review and Meta-analysis of Antiretroviral Therapy (ART) Adherence Interventions for Women Living with HIV.
Jennifer A PellowskiDevon M PriceAbigail D HarrisonEmily L TuthillLandon MyerDon OperarioMark N LuriePublished in: AIDS and behavior (2019)
A systematic review and meta-analysis was conducted to determine the efficacy of women-focused ART adherence interventions. Included studies (a) reported on a behavioral ART adherence intervention for cis-women living with HIV, (b) measured ART adherence as an outcome, and (c) employed a randomized controlled trial design. Thirteen studies were included in the meta-analysis. Overall, interventions significantly improved ART adherence compared to control conditions (random-effects d = 0.82, 95% CI [0.18, 1.45], p = 0.01), however, this was largely driven by two studies that had effect sizes greater than 3 standard errors above the mean effect size. Key moderators were location, recruitment method, group-based intervention, and alteration of the healthcare system. Innovative behavioral interventions that focus on young women and adolescents, target the critical periods of pregnancy and postpartum and test the integration of multiple levels of intervention to create lasting effects on ART adherence are needed.
Keyphrases
- antiretroviral therapy
- hiv infected
- physical activity
- randomized controlled trial
- polycystic ovary syndrome
- case control
- systematic review
- human immunodeficiency virus
- hiv positive
- glycemic control
- pregnancy outcomes
- hiv infected patients
- hiv aids
- type diabetes
- emergency department
- metabolic syndrome
- patient safety
- insulin resistance
- preterm birth
- cervical cancer screening