Unveiling the link between genetic alterations in gamma secretase and BCMA surface density in multiple myeloma.
Andrew J CowanDamian J GreenPublished in: British journal of haematology (2023)
Cattaneo et al. report a unique case of a multiple myeloma patient with elevated B-cell maturation antigen (BCMA) surface density, potentially due to genetic alterations in the gamma-secretase protease complex-responsible for BCMA cleavage from plasma cells. No mutations in the BCMA gene were detected, but there was partial deletion of PSEN1 and amplification of PSEN2 (components of the gamma-secretase complex), which may explain the lack of response to the gamma-secretase inhibitor DAPT. This case, along with recent published literature, underscores the significance of gamma secretase in modulating BCMA density and the potential impact of its genetic alterations. Commentary on: Cattaneo et al. Genetic defects of gamma-secretase genes in a multiple myeloma patient with high and dysregulated BCMA surface density: A case report. Br J Haematol 2023 (Online ahead of print). doi: 10.1111/bjh.19168.
Keyphrases
- multiple myeloma
- genome wide
- copy number
- early onset
- systematic review
- dna methylation
- induced apoptosis
- healthcare
- randomized controlled trial
- gene expression
- coronary artery disease
- cell cycle arrest
- acute coronary syndrome
- cell death
- atrial fibrillation
- genome wide analysis
- dna binding
- bioinformatics analysis
- label free