TGF-β Pathways Stratify Colorectal Cancer into Two Subtypes with Distinct Cartilage Oligomeric Matrix Protein (COMP) Expression-Related Characteristics.
Jia-Tong DingHao-Nan ZhouYing-Feng HuangJie PengHao-Yu HuangHao YiZhen ZongZhi-Kun NingPublished in: Biomolecules (2022)
Comprehensive immune analysis and experimental validation demonstrate that COMP is a reliable signature for subtype prediction. Our results could provide a new point for TGFβ-targeted anticancer drugs and contribute to guiding clinical decision making for CRC patients.
Keyphrases
- end stage renal disease
- decision making
- transforming growth factor
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- binding protein
- cancer therapy
- epithelial mesenchymal transition
- small molecule
- drug delivery
- long non coding rna
- signaling pathway
- data analysis