Luteolin: A promising multifunctional natural flavonoid for human diseases.
Mingtao ZhuYanping SunYang SuWei GuanYu WangJianwei HanShuang WangBing-You YangQiuhong WangHaixue KuangPublished in: Phytotherapy research : PTR (2024)
Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It is noteworthy that LUT exhibits a variety of beneficial pharmacological properties and holds significant potential for clinical applications, particularly in antitumor, anti-convulsion, diabetes control, anti-inflammatory, neuroprotection, anti-oxidation, anti-cardiovascular, and other aspects. The potential mechanism of action has been partially elucidated, including the mediation of NF-κB, toll-like receptor, MAPK, Wnt/β-catenin, PI3K/Akt, AMPK/mTOR, and Nrf-2, among others. The review that aimed to comprehensively consolidate essential information on natural sources, pharmacological effects, therapeutic and preventive potential, as well as potential mechanisms of LUT. The objective is to establish a theoretical basis for the continued development and application of LUT.
Keyphrases
- human health
- pi k akt
- signaling pathway
- toll like receptor
- risk assessment
- cell proliferation
- oxidative stress
- climate change
- nuclear factor
- cardiovascular disease
- type diabetes
- anti inflammatory
- epithelial mesenchymal transition
- drug delivery
- healthcare
- hydrogen peroxide
- brain injury
- drinking water
- adipose tissue
- social support
- depressive symptoms
- lps induced
- weight loss
- health information
- social media
- cerebral ischemia