Hepatic IL22RA1 deficiency promotes hepatic steatosis by modulating oxysterol in the liver.
Yeping HuangFan YuYue DingHong ZhangXinyue LiXiao WangXiaoshan WuJie XuLiang WangChenxu TianMin JiangRong ZhangChenyan YanYingxiang SongHaijun HuangGuangzhong XuQiurong DingXiao YeYan LuCheng HuPublished in: Hepatology (Baltimore, Md.) (2024)
These findings indicate that IL22RA1 plays a crucial role in maintaining hepatic lipid homeostasis in an activating transcription factor 3/oxysterol 7 alpha-hydroxylase-dependent manner and establish a link between 3β HCA and hepatic lipid homeostasis.