The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.
Matthijs VlasveldGiulia CallegaroCiarán FisherJulie EakinsPaul WalkerSamantha LokSiddh van OostBrechtje de JongDamiano Pellegrino-CoppolaGerhard A BurgerSteven WinkBob van de WaterPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
Together, the results suggest that early pre-clinical screening for CHOP expression could indicate liability of mitochondrial toxicity in the context of DILI, and, therefore, could serve as an important warning signal to consider during decision-making in drug development.