Randomized pilot trial comparing tolvaptan with furosemide on renal and neurohumoral effects in acute heart failure.

Kentaro JujoKatsumi SaitoIssei IshidaYuho FurukiAhsung KimYuki SuzukiHaruki SekiguchiJunichi YamaguchiHiroshi OgawaNobuhisa Hagiwara

Published in: ESC heart failure (2016)

As compared with furosemide, tolvaptan in patients with acute heart failure is associated with comparable decongestion, better preservation of renal function and less activation of renin-angiotensin system. (UMIN 000014134).

Keyphrases

acute heart failure
heart failure
double blind
open label
placebo controlled
phase ii
clinical trial
randomized controlled trial
study protocol
polycystic kidney disease