Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma.

Prajna Paramita NaikSubhadip MukhopadhyayPrashanta Kumar PandaNiharika SinhaChandan Kanta DasRajakishore MishraShankargouda PatilSujit Kumar Bhutia

Published in: Cell proliferation (2017)

The CD44+ /ABCB1+ /ADAM17+ expression in OSCC is associated with stemness and chemoresistance. Further, this study highlights the involvement of mitophagy in chemoresistance and autophagic regulation of stemness in OSCC.

Keyphrases

cancer stem cells
stem cells
epithelial mesenchymal transition
poor prognosis
cell death
signaling pathway
nk cells
cell proliferation
endoplasmic reticulum stress
long non coding rna