Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke.
Jinpei LinFei XuGenfa WangLingwen KongQingli LuoYvbao LvJiaqi LiuYing WeiLulu LiHongying ZhangJing-Cheng DongPublished in: Evidence-based complementary and alternative medicine : eCAM (2016)
Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.
Keyphrases
- oxidative stress
- reactive oxygen species
- dna damage
- diabetic rats
- chronic obstructive pulmonary disease
- ischemia reperfusion injury
- induced apoptosis
- gestational age
- lung function
- blood pressure
- cell death
- heat shock
- smoking cessation
- randomized controlled trial
- clinical trial
- combination therapy
- anti inflammatory
- double blind