Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome.

Benjamin D S ClarksonReghann G LaFrance-CoreyRobert J KahoudRaquel Farias-MoellerEric T PayneCharles L Howe

Published in: Annals of neurology (2019)

Our findings suggest that FIRES is associated with reduced expression of intracellular IL1RA isoforms and a functional deficiency in IL1RA inhibitory activity. These observations may provide insight into disease pathogenesis for FIRES and other inflammatory seizure disorders and may provide a valuable biomarker for therapeutic decision-making. Ann Neurol 2019;85:526-537.

Keyphrases

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