Membrane Proteome-Wide Screening of Autoantibodies in CIDP Using Human Cell Microarray Technology.
Marta Caballero-ÁvilaCinta LleixàElba Pascual-GoñiLorena Martín-AguilarNúria Vidal-FernandezClara Tejada-IllaRoger Collet-VidiellaRicardo Rojas-GarcíaElena Cortés-VicenteJanina Turon-SansEduard GallardoMontse OlivéAna VesperinasÁlvaro CarbayoLaura LlansóLaura Martinez-MartinezAnthony ShockLouis ChristodoulouBenjamin DizierJim FreethJo SodenSarah DawsonLuis Antonio Querol-GutiérrezPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
Our work demonstrates the utility of human cell microarray technology to detect known and discover unknown autoantibodies in human serum samples. Despite potential CIDP-associated autoantibodies (anti-LIF and anti-IFNL3) being identified, their clinical and pathogenic relevance needs to be elucidated in bigger cohorts.