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Membrane Proteome-Wide Screening of Autoantibodies in CIDP Using Human Cell Microarray Technology.

Marta Caballero-ÁvilaCinta LleixàElba Pascual-GoñiLorena Martín-AguilarNúria Vidal-FernandezClara Tejada-IllaRoger Collet-VidiellaRicardo Rojas-GarcíaElena Cortés-VicenteJanina Turon-SansEduard GallardoMontse OlivéAna VesperinasÁlvaro CarbayoLaura LlansóLaura Martinez-MartinezAnthony ShockLouis ChristodoulouBenjamin DizierJim FreethJo SodenSarah DawsonLuis Antonio Querol-Gutiérrez
Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)
Our work demonstrates the utility of human cell microarray technology to detect known and discover unknown autoantibodies in human serum samples. Despite potential CIDP-associated autoantibodies (anti-LIF and anti-IFNL3) being identified, their clinical and pathogenic relevance needs to be elucidated in bigger cohorts.
Keyphrases
  • endothelial cells
  • systemic lupus erythematosus
  • single cell
  • cell therapy
  • induced pluripotent stem cells
  • pluripotent stem cells
  • mesenchymal stem cells
  • bone marrow
  • climate change