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Photoinduced Remote C(sp 3 )-H Phosphonylation of Amides.

Jian WangYuchen ZhangLin ZhuXiao-Song XueChaozhong Li
Published in: Angewandte Chemie (International ed. in English) (2024)
The present study reports an unprecedented protocol for the phosphonylation of unactivated C(sp 3 )-H bonds. By utilizing 1 mol % 4DPAIPN (1,2,3,5-tetrakis(diphenylamino)-4,6-dicyanobenzene) as the catalyst, satisfactory yields of γ-phosphonylated amides are obtained through a visible-light-induced reaction between N-((4-cyanobenzoyl)oxy)alkanamides and 9-fluorenyl o-phenylene phosphite at room temperature. This protocol demonstrates broad substrate scope and wide functional group compatibility.
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