Physicochemical property evaluation of modified oligonucleotides by traveling-wave ion mobility mass spectrometry.
Shogo OmuroTakao YamaguchiTaiji KawaseMaki TerasakiKenji HiroseSatoshi ObikaPublished in: Rapid communications in mass spectrometry : RCM (2022)
The TWIMS results showed a correlation between the length and modification of oligonucleotides and the CCS values. In addition, it suggested that each charge state of the oligonucleotide ion has different physicochemical properties.