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Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.

Fei ZengKarsten ParkerYanqiang ZhanMatthew MillerMeng-Yang Zhu
Published in: ASN neuro (2023)
The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.
Keyphrases
  • dna damage
  • oxidative stress
  • dna repair
  • high fat diet induced
  • mouse model
  • poor prognosis
  • machine learning
  • insulin resistance
  • neoadjuvant chemotherapy
  • circulating tumor
  • long non coding rna
  • brain injury
  • wild type