Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression.
Ming-Jer YoungYung-Ching ChenShao-An WangHui-Ping ChangWen-Bin YangChia-Chi LeeChia-Yu LiuYau-Lin TsengYi-Ching WangH Sunny SunWen-Chang ChangJan-Jong HungPublished in: Journal of biomedical science (2022)
Premenopausal women with lung cancer and decreased Sp1 levels have a poor prognosis. E2 increases RNF4 expression to repress Sp1 levels in premenopausal women with lung cancer, thus decreasing the expression of several miRNAs that can target CD44 and ultimately leading to cancer malignancy.