Sailuotong Capsule Prevents the Cerebral Ischaemia-Induced Neuroinflammation and Impairment of Recognition Memory through Inhibition of LCN2 Expression.

Yehao Zhang Jianxun LiuMingjiang YaoWenTing SongYongqiu ZhengLi XuMingqian SunBin Yang Alan Bensoussan Dennis H Chang Hao Li

Published in: Oxidative medicine and cellular longevity (2019)

SLT mediates neuroinflammation, thereby protecting against ischaemic brain injury by inhibiting astrogliosis and suppressing neuroinflammation via the LCN2-JAK2/STAT3 pathway, providing a new idea for the treatment strategy of ischaemic stroke.

Keyphrases

cerebral ischemia
lipopolysaccharide induced
lps induced
traumatic brain injury
subarachnoid hemorrhage
cognitive impairment
signaling pathway
blood brain barrier
brain injury
poor prognosis
inflammatory response
high glucose
white matter
combination therapy
multiple sclerosis
drug induced
smoking cessation