CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells.

Sana NasimJill Wylie-SearsXinlei GaoQianman PengBo ZhuKaifu Chen Hong Chen Joyce Bischoff

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

CD45 is sufficient to incite an EndMT phenotype and acquisition of mesenchymal cell properties in normal human ECFCs. We speculate that CD45, through its C-terminal PTPase domain, initiates signaling events that drive EndMT.

Keyphrases

endothelial cells
high glucose
bone marrow
stem cells
nk cells
single cell
cell therapy