Interaction of a genetic risk score with physical activity, physical inactivity, and body mass index in relation to venous thromboembolism risk.

Jihye KimPeter KraftKaitlin A HaganLaura B HarringtonSara LindstroemChristopher Kabrhel

Published in: Genetic epidemiology (2018)

We found a synergetic effect between a genetic risk score and high BMI on the risk of VTE. Intervention efforts lowering BMI to decrease VTE risk may have particularly large beneficial effects among individuals with high genetic risk.

Keyphrases

venous thromboembolism
body mass index
physical activity
genome wide
randomized controlled trial
weight gain
direct oral anticoagulants
mental health
atrial fibrillation