Investigating the relationship between depression and breast cancer: observational and genetic analyses.

Xueyao WuWenqiang ZhangXunying ZhaoLi ZhangMinghan XuYu HaoJinyu XiaoBen ZhangJiayuan LiPeter KraftJordan W SmollerXia Jiang

Published in: BMC medicine (2023)

Our work demonstrates a shared genetic basis, pleiotropic loci, and a putative causal relationship between depression and BC, highlighting a biological link underlying the observed phenotypic relationship; these findings may provide important implications for future studies aimed reducing BC risk.

Keyphrases

genome wide
depressive symptoms
sleep quality
copy number
dna methylation
current status
gene expression
cross sectional
genome wide association
breast cancer risk
childhood cancer