High-fat diet decreases H3K27ac in mice adipose-derived stromal cells.
Viviane S da SilvaJussara J SimãoVictor PlataAndressa França de SousaRoberta D C da Cunha de SáCleiton Fagundes MachadoTaiza StumppMaria Isabel Cardoso Alonso ValeLucia Maria Armelin-CorreaPublished in: Obesity (Silver Spring, Md.) (2022)
These results show that an HFD significantly reduces acetylation of H3K27 in ASCs and the expression of ATP-citrate lyase in subcutaneous ASCs, suggesting that, in this fat depot, the H3K27ac reduction could be partly due to lower acetyl-coenzyme A availability. H3K27ac is an epigenetic mark responsible for increasing the transcription rate and its reduction can have an important impact on ASC proliferation and differentiation potential.