Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli.
Marcel HulstRommie van der WeideArjan HoekmanMarinus van KrimpenPublished in: Genes & nutrition (2019)
Exposure of by ETEC stressed intestinal epithelium cells to micro algae extracts affected "fatty acid β-oxidation", ATP and reactive oxygen species production and (de) hydroxylation of lysine residues in procollagen chains in these cells. Elevated gene expression of specific EPs and immunostimulatory proteins indicated that micro algae extracts, when used as feed/food additive, can steer an array of metabolic and immunological processes in the intestines of humans and monogastric animals stressed by an enteric bacterial pathogen.
Keyphrases
- gene expression
- induced apoptosis
- escherichia coli
- cell cycle arrest
- reactive oxygen species
- fatty acid
- dna methylation
- transcription factor
- signaling pathway
- endoplasmic reticulum stress
- cell death
- risk assessment
- endothelial cells
- cystic fibrosis
- nitric oxide
- staphylococcus aureus
- pi k akt
- human health
- climate change
- mass spectrometry
- klebsiella pneumoniae
- amino acid
- high density
- heat shock