Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma.
Lei DongShuo YouQing ZhangSatoru OsukaNarra S DeviStefan KaluzJalisa H FergusonHua YangGuoliang ChenBinghe WangHans E GrossniklausErwin G Van MeirPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Our preclinical efficacy studies support the further optimization of the 64B chemical scaffold toward a clinical candidate for the treatment of UM.