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Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts.

Hexia GuoWubin BaiWei OuyangYihan LiuChangsheng WuYameng XuYang WengHao ZangYiming LiuLauren JacobsonZiying HuYihang WangHany M ArafaQuansan YangDi LuShuo LiLin ZhangXun XiaoAbraham Vázquez-GuardadoJoanna CiattiElizabeth M Higbee-DempseyNayereh Ghoreishi-HaackEmily Alexandria WatersChad R HaneyAmanda M WestmanMatthew R MacEwanMitchell A PetJohn A Rogers
Published in: Nature communications (2022)
Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O 2 -sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.
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