The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis.

Huifang LiHaoyan HuangXiaoniao ChenShang ChenLu YuChen WangYue LiuKaiyue ZhangLingling WuZhong-Chao HanNa LiuJie WuZongjin Li

Published in: Stem cell research & therapy (2021)

Hsa-miR-11401 expressed by MSCs can be transported to chemotherapy-damaged cells by EVs, reducing the high expression of SCOTIN in damaged cells, thereby inhibiting SCOTIN-mediated apoptosis.

Keyphrases

cell proliferation
induced apoptosis
long non coding rna
cell cycle arrest
poor prognosis
signaling pathway
long noncoding rna
mesenchymal stem cells
stem cells
endoplasmic reticulum stress
cell death
bone marrow
drug delivery
high glucose
pi k akt
endothelial cells
locally advanced
binding protein
umbilical cord