Therapeutic Effects of Treating COVID-19 Vaccine-Induced Anti-TIF1-γ-Positive Dermatomyositis.
Chih-Feng WuWan-Ting ChenYen-Lin ChenFeng-Cheng LiuPublished in: Medicina (Kaunas, Lithuania) (2023)
An increase in skin-related autoimmune disorders has been reported as an adverse effect of coronavirus disease 2019 (COVID-19) vaccines. We present the case of a 90-year-old Taiwanese female who was newly diagnosed with anti-transcription intermediary factor 1-gamma (anti-TIF1-γ)-positive dermatomyositis (DM) after receiving a second dose of the AstraZeneca COVID-19 vaccine. Under treatment with prednisolone and monoclonal antibody therapy of abatacept, her skin lesions improved, and her muscle power increased. The serum creatinine phosphokinase level decreased from 4858 to 220 U/L, and the anti-TIF1-γ antibody titer decreased from 202 to 99. Flow cytometry data showed an increase in T cells, while NK cells, B cells (CD19), and plasma blasts all decreased. These findings suggest that standard DM treatment might be beneficial to patients with COVID-19 vaccine-induced DM.
Keyphrases
- coronavirus disease
- sars cov
- monoclonal antibody
- flow cytometry
- nk cells
- newly diagnosed
- respiratory syndrome coronavirus
- high glucose
- diabetic rats
- rheumatoid arthritis
- drug induced
- skeletal muscle
- soft tissue
- emergency department
- wound healing
- oxidative stress
- glycemic control
- uric acid
- adipose tissue
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- systemic sclerosis
- cell therapy
- rheumatoid arthritis patients