Representativeness in randomised clinical trials supporting acute coronary syndrome guidelines.
Caterina Mas-LladoMaribel Gonzalez-Del-HoyoJoan Siquier-PadillaLaura Blaya-PeñaJ J CoughlanBernardo García de la VillaVicente PeralXavier RosselloPublished in: European heart journal. Quality of care & clinical outcomes (2023)
RCTs supporting CPGs for ACS are not fully representative of the diversity of the ACS population and their current standard of care. While some of these issues with representativeness may be explained by how evidence has been accrued over time, efforts should be made by trialists to ensure that the evidence supporting CPGs is representative of the wider ACS population.