Lumican is elevated in the lung in human and experimental acute respiratory distress syndrome and promotes early fibrotic responses to lung injury.
Ke WangYouyu WangYufang CaoHao WangYongfang ZhouLijuan GaoZijian ZengMengxin ChengXiaodong JinJun ChenFu-Qiang WenTao WangPublished in: Journal of translational medicine (2022)
Pulmonary lumican levels were increased early in human and experimental ARDS and linked to disease severity and inflammatory fibrotic processes. Lumican triggers the transdifferentiation of lung fibroblasts into myofibroblasts and epithelial-mesenchymal transition in SAECs, possibly via the ERK/Slug pathway. Knockdown of pulmonary lumican attenuated extracellular matrix deposition in ALI mice. Overall, lumican promotes fibrotic responses in the early phase of ARDS, suggesting its potential as a therapeutic target.
Keyphrases
- acute respiratory distress syndrome
- extracellular matrix
- epithelial mesenchymal transition
- extracorporeal membrane oxygenation
- mechanical ventilation
- endothelial cells
- systemic sclerosis
- pulmonary hypertension
- idiopathic pulmonary fibrosis
- signaling pathway
- induced pluripotent stem cells
- pluripotent stem cells
- transforming growth factor
- type diabetes
- intensive care unit
- adipose tissue
- pi k akt
- metabolic syndrome