Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion-symptom mapping study in 3525 memory clinic patients.
Mirthe CoenenHugo J KuijfIrene M C Huenges WajerMarco DueringFrank J WoltersEvan F FletcherPauline M Maillardnull nullFrederik BarkhofJosephine BarnesThomas BenkeJooske M F BoomsmaChristopher P L H ChenPeter Dal-BiancoAnna DewenterChristian EnzingerMichael EwersLieza G ExaltoNicolai FranzmeierOnno GroeneveldSaima HilalEdith HoferDineke L KoekAndrea B MaierCheryl R McCrearyCatarina S PadillaJanne M PapmaRoss W PatersonYolande A L PijnenburgAnna RubinskiReinhold SchmidtJonathan M SchottCatherine F SlatteryEric E SmithRebecca M E SteketeeCarole H SudreEsther van den BergWiesje M van der FlierNarayanaswamy VenketasubramanianMeike W VernooijXu XinCharles DeCarliGeert Jan BiesselsJ Matthijs BiesbroekPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.