The Nonproteolytic Intracellular Domain of Membrane-Type 1 Matrix Metalloproteinase Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis in Mice-Brief Report.
Michele SilvestroCristobal F RiveraDornazsadat AlebrahimJohn VlahosMuhammad Yogi PratamaCuijie LuClaudia TangZander HarpelRayan Sleiman TellaouiAriadne L ZiasDelphina J MaldonadoDevon ByrdMukundan AtturPaolo MignattiBhama RamkhelawonPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Our findings show that the cytoplasmic domain of MT1-MMP safeguards from AAA and atherosclerotic plaque development through a proteolysis-independent signaling mechanism associated with Netrin-1 expression. This unexpected function of MT1-MMP unveils a novel mechanism of synchronous onset of AAA and atherogenesis and highlights its importance in the control of vascular wall homeostasis.