Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway.

Cheol Park Eun Ok Choi Hyun HwangBo Hyesook Lee Jin-Woo Jeong Min Ho Han Sung-Kwon Moon Seok-Joong Yun Wun Jae Kim Gi Young Kim Hye-Jin Hwang Young Hyun Choi

Published in: Nutrition research and practice (2021)

Taken together, our results indicate that exposure to EEZS exhibits anti-cancer activity in T24 bladder cancer cells through ROS-dependent induction of apoptosis and inactivation of the PI3K/Akt signaling pathway.

Keyphrases

cell death
cell cycle arrest
signaling pathway
pi k akt
induced apoptosis
endothelial cells
oxidative stress
epithelial mesenchymal transition
endoplasmic reticulum stress
spinal cord injury
induced pluripotent stem cells
cell proliferation
dna damage
pluripotent stem cells
urinary tract