Preservation of β-cell function in pancreatic insufficient cystic fibrosis with highly effective CFTR modulator therapy.
Anneliese Js FlattSaba SheikhAmy J PeleckisPaola AlvaradoDenis HadjiliadisDarko StefanovskiRobert J GallopRonald C RubensteinAndrea KellyMichael R RickelsPublished in: The Journal of clinical endocrinology and metabolism (2023)
ETI preserves β-cell function in CF through effects on glucose-dependent insulin secretion, proinsulin processing and meal-related insulin secretion. Further work should determine whether early intervention with ETI can prevent deterioration of glucose tolerance in PI-CF.