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Safety, tolerability, pharmacokinetics, and antitumour activity of oleclumab in Japanese patients with advanced solid malignancies: a phase I, open-label study.

Shunsuke KondoSatoru IwasaTakafumi KoyamaTomoko FujitaKo SugibayashiKosho MurayamaNoboru Yamamoto
Published in: International journal of clinical oncology (2022)
Oleclumab was well tolerated in adult Japanese patients with advanced solid malignancies and no unexpected safety concerns were raised; oleclumab exposure increased with dose. Future studies on combination therapy with other agents are warranted.
Keyphrases
  • combination therapy
  • open label
  • clinical trial
  • phase ii
  • phase ii study
  • current status
  • study protocol
  • randomized controlled trial
  • squamous cell carcinoma
  • young adults
  • case control
  • radiation therapy