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KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m 6 A reader YTHDC1 protein degradation.

Yi YangYingwen ZhangGuoyu ChenBowen SunFei LuoYijin GaoHaizhong FengYanxin Li
Published in: Journal of experimental & clinical cancer research : CR (2024)
A modification by STM2457, a small-molecule inhibitor of METTL3, could downregulate MYCN expression and attenuate tumor proliferation. This finding provides a new alternative putative therapeutic strategy for MYCN-amplified NB.
Keyphrases
  • small molecule
  • protein protein
  • binding protein
  • poor prognosis
  • signaling pathway
  • nucleic acid
  • long non coding rna