Efficacy and Safety of High-Dose Rifampin in Pulmonary Tuberculosis. A Randomized Controlled Trial.

Gustavo E VelásquezMeredith B BrooksJulia M CoitHenry PertinezDante Vargas VásquezEpifanio Sánchez GaravitoRoger I CalderónJudith JiménezKaren TintayaCharles A PeloquinElna OssoDylan B TierneyKwonjune J SeungLeonid LeccaGeraint R DaviesCarole D Mitnick

Published in: American journal of respiratory and critical care medicine (2019)

Our findings of more rapid sputum sterilization and similar toxicity with higher rifampin doses support investigation of increased rifampin doses to shorten tuberculosis treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01408914) .

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
high dose
clinical trial
low dose
oxidative stress
randomized controlled trial
stem cell transplantation
study protocol
double blind
phase ii
cystic fibrosis
open label
phase iii
hiv aids
replacement therapy
drug induced
oxide nanoparticles