M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition.
Claudia GuerrieroMarianna ManfredelliCarlo MateraAngela IuzzolinoLuciano ContiClelia DallanoceMarco De AmiciDaniela TrisciuoglioAda Maria TataPublished in: Cancers (2023)
N8 treatment causes autophagy via pAMPK upregulation, followed by apoptosis in both investigated cell lines. In contrast, the absence of autophagy in APE-treated GSC cells seems to indicate that cell death could be triggered by mechanisms alternative to those observed for N8.
Keyphrases
- cell death
- cell cycle arrest
- endoplasmic reticulum stress
- induced apoptosis
- cancer stem cells
- signaling pathway
- oxidative stress
- endothelial cells
- cell proliferation
- pi k akt
- magnetic resonance
- poor prognosis
- magnetic resonance imaging
- computed tomography
- combination therapy
- binding protein
- long non coding rna
- high speed
- replacement therapy