Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients.

Sumayya Abdul Sattar RealFarah ParveenAsad Ur RehmanMohammad Aasif KhanSankaravamasam Venkata Suryanarayan DeoNootan Kumar ShuklaSyed Akhtar Husain

Published in: BMC cancer (2018)

The expression of YAP was found to be downregulated in response to aberrant promoter methylation. The downregulation of YAP are consistent with previous studies suggesting it to have a tumor suppressive role in breast cancer. We did not observe any mutation at the major check point sites in the Hippo pathway.

Keyphrases

dna methylation
genome wide
cell proliferation
gene expression
transcription factor
signaling pathway
poor prognosis
copy number
genome wide identification
long non coding rna
case control
breast cancer risk