Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cells.

Kai ShanNinghan FengDoudou ZhuHongyan QuGuoling FuJiaqi LiJing CuiHeyan ChenRong WangYumin QiYongquan Chen

Published in: European journal of nutrition (2022)

DHA can effectively promote ferroptosis-mediated tumor killing by increasing intracellular lipid peroxidation. Both ALOX5 dependent and independent pathways are involved in DHA-FIN induced ferroptosis. And during this process, free DHA plays an important role.

Keyphrases

cell death
fatty acid
cell cycle arrest
high glucose