Toxoplasma gondii suppress human cord blood cell differentiation to the NK cell population.

Sepideh MahmoudzadehKhadijeh Dizaji AslHojjatollah Nozad CharoudehReza RahbarghaziMahdi AhmadiMorteza HeidarzadehAdel SpotinEhsan Ahmadpour

Published in: Immunity, inflammation and disease (2024)

Our findings suggest that virulent T. gondii tachyzoites with cytopathic effects inhibit NK cell activation and eliminate innate immune responses during infection, and consequently enable the parasite to continue its survival in the host body.

Keyphrases

nk cells
toxoplasma gondii
cord blood
immune response
endothelial cells
dendritic cells
toll like receptor
induced pluripotent stem cells
pluripotent stem cells
plasmodium falciparum