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The Antitumor and Immunomodulatory Effect of Yanghe Decoction in Breast Cancer Is Related to the Modulation of the JAK/STAT Signaling Pathway.

Dan MaoLei FengHui Gong
Published in: Evidence-based complementary and alternative medicine : eCAM (2018)
Our results showed that The mechanisms of YHD inhibit 4T1 breast tumor growth may be related to downregulating the expression of iNOS and ARG-1, negatively regulating the Janus kinase/STAT3 (JAK/STAT3) pathway by repressing the expression of IL-6 and TGF-β. Meanwhile, YHD enhances the immune capacity via increasing the expression of NKTs, CD4+ T cells, IFN-γ, and p-STAT1.
Keyphrases
  • poor prognosis
  • signaling pathway
  • binding protein
  • epithelial mesenchymal transition
  • young adults
  • protein kinase
  • nitric oxide synthase
  • endoplasmic reticulum stress