The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma.

Shufang JinMingyu LiHanyue ChangRuijie WangZhiyuan ZhangJianjun ZhangYue HeHai-Long Ma

Published in: Molecular cancer (2022)

These findings unveil a novel mechanism of immune microenvironment regulation mediated by m6A modification through the ALKBH5/RIG-I/IFNα axis, providing a rationale for therapeutically targeting epitranscriptomic modulators in HNSCC.

Keyphrases

poor prognosis
dendritic cells
long non coding rna
small molecule
immune response
stem cells
signaling pathway
cancer therapy
clinical trial
binding protein
drug delivery