Taicrypnacids A and B, a Pair of C37 Heterodimeric Diterpenoid Stereoisomers from Taiwania cryptomerioides.
Wen-Li WangDong-Rong ZhuChen ChenTian-Yu ZhuChao HanFei-Yan LiuLing-Nan LiJian-Guang LuoLing-Yi KongPublished in: Journal of natural products (2019)
Two uncommon C37 heterodimeric diterpenoids, taicrypnacids A (1) and B (2), and a known labdane-type diterpenoid (3) were isolated from the leaves of Taiwania cryptomerioides. Several techniques, such as comprehensive spectroscopic analysis, chemical conversion, X-ray crystallography, and ECD data, were employed to define the structures. The two new compounds displayed cytotoxicity against human breast cancer (MCF-7), osteosarcoma (U-2 OS), and human colon carcinoma (HCT-116) cell lines, while the methyl ester 1a showed no activity. Compound 1 induced Ca2+-ROS pathway-mediated endoplasmic reticulum stress, and excessive stress led to cell death by activating apoptosis and autophagy.
Keyphrases
- endoplasmic reticulum stress
- cell death
- cell cycle arrest
- induced apoptosis
- endothelial cells
- high glucose
- signaling pathway
- oxidative stress
- pluripotent stem cells
- induced pluripotent stem cells
- high resolution
- body mass index
- dna damage
- big data
- electronic health record
- diabetic rats
- molecular docking
- pi k akt
- cell proliferation
- computed tomography
- physical activity
- stress induced
- drug induced
- deep learning