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Systematic identification of genetic influences on methylation across the human life course.

Tom R GauntHashem A ShihabGibran HemaniJosine L MinGeoff WoodwardOliver LyttletonJie ZhengAparna DuggiralaWendy L McArdleKaren HoSusan M RingDavid M EvansGeorge Davey SmithCaroline L Relton
Published in: Genome biology (2016)
DNA methylation contains a significant heritable component that remains consistent across the lifespan. Our results suggest that the genetic component of methylation may have a causal role in complex traits. The database of mQTL presented here provide a rich resource for those interested in investigating the role of methylation in disease.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • gene expression
  • endothelial cells
  • pluripotent stem cells
  • induced pluripotent stem cells
  • emergency department