Systematic identification of genetic influences on methylation across the human life course.

Tom R GauntHashem A ShihabGibran HemaniJosine L MinGeoff WoodwardOliver LyttletonJie ZhengAparna DuggiralaWendy L McArdleKaren HoSusan M RingDavid M EvansGeorge Davey SmithCaroline L Relton

Published in: Genome biology (2016)

DNA methylation contains a significant heritable component that remains consistent across the lifespan. Our results suggest that the genetic component of methylation may have a causal role in complex traits. The database of mQTL presented here provide a rich resource for those interested in investigating the role of methylation in disease.

Keyphrases

genome wide
dna methylation
copy number
gene expression
endothelial cells
pluripotent stem cells
induced pluripotent stem cells
emergency department