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Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.

Edward A MoteaFarjana J FattahLing XiaoLuc GirardAmy RommelJulio C MoralesPraveen PatidarYunyun ZhouAndrew PorterYang XieJohn D MinnaDavid A Boothman
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Cancer cells with low K-H expression may have exploitable BRCAness properties that greatly expand the use of PARP inhibitors beyond BRCA mutations. Our results suggest that aberrant K-H alterations may have vital translational implications in cellular responses/survival to DNA damage, carcinogenesis, and personalized medicine.
Keyphrases
  • dna damage
  • dna repair
  • poor prognosis
  • oxidative stress
  • breast cancer risk
  • climate change
  • free survival
  • binding protein
  • young adults