Sarcopenic obesity in early breast cancer patients with metabolic syndrome: a cross-sectional study.
Gülcan BulutNesrin AtciPublished in: Future oncology (London, England) (2022)
Aim: The importance of sarcopenic obesity (SO) in malignancy has recently been recognized. The authors aimed to investigate the clinical and body composition data of early-stage breast cancer (BC) patients by focusing on the components of metabolic syndrome (MetS) and SO. Methods: In this cross-sectional study with early-stage BC patients, the clinical and laboratory results were evaluated for diagnosing MetS. Bioimpedance analysis and muscle radiation attenuation (Hounsfield unit average calculation [HUAC]) using acquired computed tomography images were used to assess SO. Results: The age at diagnosis, BMI, visceral fat ratio, hemoglobin A1c and CEA levels in patients with MetS were significantly higher (p < 0.05). A cutoff value of 39.4 Hounsfield units was significantly related to MetS with 76.5% sensitivity and 62% specificity. The mean HUAC in patients with MetS (36.9) was significantly lower than in those without MetS (41.4; p = 0.017). Conclusion: HUAC value predicted SO in early-stage BC patients with MetS.
Keyphrases
- early stage
- metabolic syndrome
- body composition
- insulin resistance
- end stage renal disease
- computed tomography
- ejection fraction
- chronic kidney disease
- type diabetes
- weight gain
- skeletal muscle
- physical activity
- body mass index
- early breast cancer
- magnetic resonance imaging
- deep learning
- high fat diet induced
- uric acid
- squamous cell carcinoma
- cardiovascular disease
- machine learning
- optical coherence tomography
- radiation therapy
- fatty acid
- cardiovascular risk factors
- locally advanced
- contrast enhanced
- drug induced
- red blood cell