A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile .

Monica Rosas-LemusSupratim DeyGeorge MinasovKemin TanSpencer M AndersonJoseph BrunzelleSalvatore NocadelloIvan ShabalinEkaterina FilippovaAndrei HalavatyYoungchang KimNatalia MaltsevaJerzy OsipiukWladek MinorAndrzej JoachimiakAlexei SavchenkoWayne F AndersonKarla J F Satchellnull null

Published in: Microbiology resource announcements (2023)

Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

Keyphrases

clostridium difficile
antimicrobial resistance
high resolution
high throughput
single cell
dual energy
candida albicans
transcription factor
mass spectrometry
electron microscopy
magnetic resonance imaging
gene expression