Rapid versus slow withdrawal of antiepileptic monotherapy in two-year seizure-free adults patients with epilepsy (RASLOW) study: A pragmatic multicentre, prospective, randomized, controlled study.

Edoardo FerlazzoGiorgia GiussaniSara GaspariniElisa BianchiVittoria CianciVincenzo BelcastroRoberto CantelloGionata StrigaroMatilde LazzariAmedeo BianchiMartina GuadagniSilvia PradellaAngela La NeveTeresa FrancavillaNicola PilolliPaola BanfiFrancesco TurcoMarta PiccioliLuigi PolidoriTeresa Anna CantisaniRossella PapettiMichela CecconiElisabetta PupilloEmilio Davide ArippolGabriele EniaSabrina NeriUmberto AgugliaEttore Beghi

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)

Seizure-relapse rate after drug discontinuation is lower than in other reports, without complications and unrelated to the duration of tapering.

Keyphrases

double blind
open label
study protocol
temporal lobe epilepsy
clinical trial
placebo controlled
adverse drug
risk factors
phase ii
combination therapy
cross sectional
emergency department
free survival
cord blood